CST – Computer Simulation Technology

A multi-sample 94 GHz dissolution dynamic-nuclear-polarization system

A multi-sample 94 GHz dissolution dynamic-nuclear-polarization system
Michael Batel, Marcin Krajewski, Kilian Weiss, Oliver With, Alexander Däpp, Andreas Hunkeler, Martin Gimersky, Klaas P. Pruessmann , Peter Boesiger, Beat H. Meier, Sebastian Kozerke, Matthias Ernst
Journal of Magnetic Resonance
Volume: 214, Issue: 1, January 2012
Dynamic nuclear polarization, Dissolution DNP, Multi-sample DNP, Hyperpolarization, Longitudinal detection EPR (LOD), Hardware
We describe the design and initial performance results of a multi-sample dissolution dynamicnuclear-polarization (DNP) polarizer based on a Helium-temperature NMR cryostat for use in a wide-bore NMR magnet with a room-temperature bore. The system is designed to accommodate up to six samples in a revolver-style sample changer that allows changing samples at liquid-Helium temperature and at pressures ranging from ambient pressure down to 1 mbar. The multi-sample setup is motivated by the desire to do repetitive in vivo measurements and to characterize the DNP process by investigating samples of different chemical composition. The system can be loaded with up to six samples simultaneously to reduce sample loading and unloading. Therefore, series of experiments can be carried out faster and more reliably. The DNP probe contains an oversized microwave cavity and includes EPR and NMR capabilities for monitoring the DNP process. In the solid state, DNP enhancements corresponding to 45% polarization for [1-13C]pyruvic acid with a trityl radical have been measured. In the initial liquid-state acquisition experiments described here, the polarization was found to be 13%, corresponding to an enhancement factor exceeding 16,000 relative to thermal polarization at 9.4 T and ambient temperature.

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