INTEGRATEDWAVEGUIDE STRUCTURE FOR HIGHLY SENSITIVE THZ SPECTROSCOPY OF NANO-LITER LIQUIDS IN CAPILLARY TUBES
V. Matvejev, C. de Tandt, W. Ranson, J. Stiens, R. Vounckx, D. Mangelings
Progress In Electromagnetics Research
Volume: 121, 1 September 2011
Terahertz dielectric spectroscopy permits the study of biomolecular interactions. However, water induces high attenuation of electromagnetic waves in the THz frequency range, obscuring
the response of biomolecules. The developed sensor overcomes this
problem by concentrating the THz wave propagating in an integrated
waveguide on a small liquid volume contained within a capillary tube.
Detailed electromagnetic modeling shows e®ective interaction between the THz waves and liquids. Transmission measurement results for capillary tubes ¯lled with water and methanol mixtures demonstrate a substantial increase in sensitivity to changes of liquid permittivity. The current integrated sensor facilitates THz spectroscopy of biological liquids: a case study on bu®ered human serum albumin solution demonstrates a great potential to complement biochemical analytical tools.
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